Familial aggregation of Parkinson's disease: The Mayo Clinic family study
Identifieur interne : 001633 ( Main/Exploration ); précédent : 001632; suivant : 001634Familial aggregation of Parkinson's disease: The Mayo Clinic family study
Auteurs : Walter A. Rocca [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Kari J. Strain [États-Unis] ; James H. Bower [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Alexis Elbaz [États-Unis] ; Daniel J. Schaid [États-Unis] ; Demetrius M. Maraganore [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2004-10.
Abstract
Data on the familial aggregation of Parkinson's disease (PD) remain conflicting. We conducted a historical cohort study of 1,001 first‐degree relatives of 162 probands with PD and of 851 relatives of 147 control probands representative of the population of Olmsted County, Minnesota (from 1976 through 1995). In addition, we studied 2,713 first‐degree relatives of 411 probands with PD referred to the Mayo Clinic from 1996 through 2000 and 625 spouses of PD or control probands. Whenever possible, relatives were interviewed and screened for parkinsonism either directly or through a proxy, and those who screened positive were examined or a copy of their medical record was obtained to confirm the diagnosis (family study method). Thirty relatives of population‐based PD probands, 18 relatives of population‐based control probands, 65 relatives of referral PD probands, and 8 spouses had developed PD. Combining population‐based with referral PD probands and population‐based control probands with spouses, the relative risk was modestly increased (relative risk, 1.71; 95% confidence interval, 1.11–2.64). Relatives of probands with younger onset (≤66 years; first tertile) had a more significantly increased risk (relative risk, 2.62; 95% confidence interval, 1.66–4.15), whereas relatives of probands with later onset had no increased risk. The relative risk decreased when the incidence of all types of parkinsonism was considered. Ann Neurol 2004;56:495–502
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DOI: 10.1002/ana.20228
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Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="495">495</biblScope><biblScope unit="page" to="502">502</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">8BDDD3FE74DF0DFA001E264EFEC1252C5E2EEE32</idno><idno type="DOI">10.1002/ana.20228</idno><idno type="ArticleID">ANA20228</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data on the familial aggregation of Parkinson's disease (PD) remain conflicting. We conducted a historical cohort study of 1,001 first‐degree relatives of 162 probands with PD and of 851 relatives of 147 control probands representative of the population of Olmsted County, Minnesota (from 1976 through 1995). In addition, we studied 2,713 first‐degree relatives of 411 probands with PD referred to the Mayo Clinic from 1996 through 2000 and 625 spouses of PD or control probands. Whenever possible, relatives were interviewed and screened for parkinsonism either directly or through a proxy, and those who screened positive were examined or a copy of their medical record was obtained to confirm the diagnosis (family study method). Thirty relatives of population‐based PD probands, 18 relatives of population‐based control probands, 65 relatives of referral PD probands, and 8 spouses had developed PD. Combining population‐based with referral PD probands and population‐based control probands with spouses, the relative risk was modestly increased (relative risk, 1.71; 95% confidence interval, 1.11–2.64). Relatives of probands with younger onset (≤66 years; first tertile) had a more significantly increased risk (relative risk, 2.62; 95% confidence interval, 1.66–4.15), whereas relatives of probands with later onset had no increased risk. The relative risk decreased when the incidence of all types of parkinsonism was considered. Ann Neurol 2004;56:495–502</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name><name sortKey="Strain, Kari J" sort="Strain, Kari J" uniqKey="Strain K" first="Kari J." last="Strain">Kari J. 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